Conformational modulation of peptides using β-amino benzenesulfonic acid ((S)Ant).
نویسندگان
چکیده
This communication describes the utility of a conformationally restricted aromatic β-amino acid (2-aminobenzenesulfonic acid, (S)Ant) inducing various folding interactions in short peptides. Sandwiching (S)Ant between diverse amino acid residues was shown to form robust folded architectures featuring a variety of H-bonded networks, suggesting its utility in inducing peptide folding.
منابع مشابه
Conformational modulation of peptide secondary structures using β-aminobenzenesulfonic acid.
This communication describes the influence of β-aminobenzenesulfonic acid ((S)Ant) on the conformational preferences of hetero foldamers. The designed (Aib-(S)Ant-Aib)n and (Aib-(S)Ant-Pro)n oligomers display a well-defined folded conformation featuring intramolecular mixed hydrogen bonding (7/11) and intra-residual (6/5) H-bonding interactions, respectively.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 7 شماره
صفحات -
تاریخ انتشار 2015